Translational Repression by Deadenylases*
نویسندگان
چکیده
منابع مشابه
Translational repression by deadenylases.
The CCR4-CAF1-NOT complex is a major cytoplasmic deadenylation complex in yeast and mammals. This complex associates with RNA-binding proteins and microRNAs to repress translation of target mRNAs. We sought to determine how CCR4 and CAF1 participate in repression and control of maternal mRNAs using Xenopus laevis oocytes. We show that Xenopus CCR4 and CAF1 enzymes are active deadenylases and re...
متن کاملThe interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets
Animal miRNAs silence the expression of mRNA targets through translational repression, deadenylation and subsequent mRNA degradation. Silencing requires association of miRNAs with an Argonaute protein and a GW182 family protein. In turn, GW182 proteins interact with poly(A)-binding protein (PABP) and the PAN2-PAN3 and CCR4-NOT deadenylase complexes. These interactions are required for the deade...
متن کاملInvestigating translational repression by microRNAs in Arabidopsis.
Regulation of gene expression by microRNAs (miRNAs) is an important facet of many developmental and physiological processes in both plants and animals. miRNAs are small (;20 to 24 nucleotides) RNAs that recognize target genes based on sequence complementarity and typically act to repress expression of the target gene, either through cleavage of the target mRNA or translational repression indepe...
متن کاملTranslational Repression in Malaria Sporozoites
Malaria is a mosquito-borne infectious disease of humans and other animals. It is caused by the parasitic protozoan, Plasmodium. Sporozoites, the infectious form of malaria parasites, are quiescent when they remain in the salivary glands of the Anopheles mosquito until transmission into a mammalian host. Metamorphosis of the dormant sporozoite to its active form in the liver stage requires tran...
متن کاملRegulation of sexual development of Plasmodium by translational repression.
Translational repression of messenger RNAs (mRNAs) plays an important role in sexual differentiation and gametogenesis in multicellular eukaryotes. Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium. The DDX6-class RNA helicase, DOZI (development of zygote inhibited), is found in a complex with mRNA species in cytoplasmi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.150763